Multicentric Intraepithelial Lesion Threat Components and Human Papillomavirus Genotypes

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Amongst girls, multicentric lesions have been related to a number of human papillomavirus (HPV) infections and a historical past of malignant tumors, in line with outcomes of a retrospective case-control research printed in BMC Infectious Ailments.

Information from girls (N=1950) present process colonoscopy-guided biopsy on the Cervical Illness Clinic of Liaoning Most cancers Hospital and Institute in China between January 1, 2018, and October 31, 2019, have been retrospectively reviewed for this research. Lesions have been assessed for genotype and HPV viral load, and demographic info, menopause standing, and scientific historical past have been obtained.

The sufferers had single cervical intraepithelial neoplasia (CIN; n=1643) or multicentric lesions (n=307). The median age of the cohort was 43 years (interquartile vary [IQR], 36-50) and 50 years (IQR, 43-55.5), 28.0% and 51.5% have been in menopause, and 0.7% and three.3% had a historical past of malignant tumors exterior of the decrease genital tract, respectively.

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Amongst sufferers with cytology outcomes, 62.5% (n=833) and 68.9% (n=184) of the multicentric and single CIN teams had irregular cytology, respectively. Sufferers with multicentric lesions have been extra more likely to be HPV optimistic (odds ratio [OR], 2.07; 95% CI, 1.03-4.15).

Median relative gentle models have been larger among the many multicentric group (median, 272.165; IQR, 1118.17 RLU/CO) in contrast with the only CIN cohort (median, 10.13; IQR, 16.70 RLU/CO).

A number of HPV infections have been detected amongst 36.5% of sufferers, and these infections have been related to multicentric lesions (OR, 1.54; 95% CI, 1.09-2.17).

The commonest high-risk genotypes within the multicentric and single cohorts have been HPV16 (39.0% vs 41.5%), HPV53 (13.6% vs 6.3%), HPV58 (12.4% vs 14.1%), and HPV52 (10.7% vs 15.1%), respectively. All low-risk genotypes have been detected amongst lower than 5% of sufferers in both group.

Multicentric lesions have been related to nongenital malignant tumors (OR, 9.58; 95% CI, 1.02-89.84), menopause (OR, 3.14; 95% CI, 2.24-4.41), and a number of HPV infections (OR, 1.47; 95% CI, 1.03-2.10).

This research could have been restricted by lack of entry to some pertinent info equivalent to variety of sexual companions or oral contraceptive use.

The research authors concluded that multicentric lesions have been related to a number of HPV infections, malignant tumors exterior the genital tract, and menopause. Steadily detected HPV genotypes have been HPV16, HPV18, HPV51, HPV52, HPV53, HPV56, and HPV58.


Zhang J, Liu G, Cui X, Yu H, Wang D. Human papillomavirus genotypes and the chance elements related to multicentric intraepithelial lesions of the decrease genital tract: a retrospective research. BMC Infect Dis. 2021;21(1):554. doi:10.1186/s12879-021-06234-0

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