Infratentorial Abnormalities Predict Ophthalmic Abnormalities in Congenital Zika Syndrome

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Infratentorial abnormalities had been discovered to be a robust predictor of ophthalmic abnormalities in kids with congenital Zika syndrome (CZS), in line with research outcomes printed within the Journal of the Pediatric Infectious Ailments Society.

On this cross-sectional research performed in Paraíba, Brazil, researchers investigated whether or not the presence or absence of infratentorial abnormalities in kids born with scientific and radiologic options of CZS was related to ophthalmic abnormalities.

The research authors outlined infratentorial abnormalities because the “presence of extreme hypoplasia or dysmorphic cerebellum and vermis cerebelli related to extreme hypoplasia or absent segmentation of the brainstem.”

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Of the 75 infants (49.3% boys) included within the research, all had mind calcifications and 53 (70.7%) introduced with microcephaly. Infratentorial abnormalities had been current in 17 infants, and 16 (94.1%) had ophthalmic abnormalities. Within the remaining 58 infants with out infratentorial abnormalities, 16 (27.6%) had ophthalmic abnormalities (odds ratio [OR], 42.0; 95% CI, 5.1-342.9; P <.001). Infants with infratentorial abnormalities had been extra prone to have macular chorioretinal atrophy (OR, 23.7; 95% CI, 6.0-93.3; P <.001) and optic nerve abnormalities (OR, 11.5; 95% CI, 3.3-40.0; P <.001). Infratentorial abnormalities had been related extra with ophthalmic abnormalities than microcephaly (94.0% vs 43.4%; P <.001).

There was a statistically important distinction in head circumference between infants with ophthalmic abnormalities (n=32) in contrast with infants with out ophthalmic abnormalities (n=43): 29.1 cm vs 30.3 cm (P =.016). Nevertheless, no important distinction in gestational age was famous between the two teams (P =.12).

Though infratentorial abnormalities had been strongly related to ophthalmic abnormalities, the absence of infratentorial abnormalities was not related to a standard ophthalmologic end result, as 16 of the 32 infants who had an ophthalmic abnormality didn’t have a radiologic predictor.

Limitations of this research embrace lack of inclusion of pregnant ladies with asymptomatic Zika virus an infection, in addition to a restricted variety of kids with gentle signs of CZS.

On condition that the presence of infratentorial abnormalities was a big predictor of ophthalmic abnormalities, the researchers advise that “All neonates of mom with attainable [Zika virus] publicity at any time throughout being pregnant ought to have an entire ophthalmologic analysis.”


Sampaio VV, Melo ASO, Coleman AL, et al. A novel radiologic discovering to foretell ophthalmic abnormalities in kids with congenital Zika syndrome. J Pediatric Infect Dis Soc. Printed on-line Might 20, 2021. doi:10.1093/jpids/piab010

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