HealthDay Information — A single 500 mg intramuscular dose of ceftriaxone is advisable for remedy of uncomplicated urogenital, anorectal, and pharyngeal gonorrhea, in accordance with up to date pointers printed within the December 18 subject of the US Facilities for Illness Management and Prevention Morbidity and Mortality Weekly Report.

Noting that 2010 pointers advisable a single 250 mg intramuscular dose of ceftriaxone and a single 1 g oral dose of azithromycin for remedy of uncomplicated gonococcal infections of the cervix, urethra, and rectum, Sancta St. Cyr, MD, from the CDC in Atlanta, and colleagues up to date earlier pointers for remedy of sexually transmitted infections brought on by Neisseria gonorrhoeae. The advice was reevaluated primarily based on rising concern for antimicrobial stewardship and the potential influence of twin remedy on commensal organisms and concurrent pathogens, in addition to consideration of a low incidence of ceftriaxone resistance and elevated incidence of azithromycin resistance.

The authors advocate a single 500-mg intramuscular dose of ceftriaxone for uncomplicated urogenital, anorectal, and pharyngeal gonorrhea. Concurrent remedy with doxycycline (100 mg orally twice a day for 7 days) is advisable in instances during which chlamydial an infection has not been dominated out.


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“The excessive frequency of pharyngeal gonorrhea with substantial underscreening and the elevated understanding of large particular person pharmacokinetic and pharmacodynamic variability has contributed to the advice for the elevated ceftriaxone dose,” the authors write.

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